WHI-P154
CAS No. : 211555-04-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $68 | In-stock |
| 10mg | $106 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $355 | In-stock |
| 100mg | $530 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13895 |
| M.Wt: | 376.20 |
| Formula: | C16H14BrN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively. IC50 & Target: IC50: 4 nM (EGFR), 1.8 μM (JAK3)[1] In Vitro: WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively[1]. WHI-P154 significantly enhances the sensitivity of ABCG2-overexpressing cells to its substrates. WHI-P154 (4 μM) moderately sensitizes ABCB1-overexpressing KB-C2 cells to its substrates whereas shows no sensitizing effect on ABCC1-, ABCC2 or ABCC10-mediated drug resistance. Moreover, WHI-P154 (4 μM) causes a significant increase in the intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. WHI-P154 alters the expression levels rather than the localization of the ABCG2 protein in ABCG2-overexpressing cells[2].
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