Dalcetrapib
CAS No. : 211513-37-0
(Synonyms: JTT-705; RO4607381)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $450 | In-stock |
| 250mg | $800 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-14950 |
| M.Wt: | 389.59 |
| Formula: | C23H35NO2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively[1][2].
IC50 & Target: IC50: 204.6 nM (rhCETP)[1], 6 μM (human plasma CETP)[2]
In Vitro: Dalcetrapib (JTT-705) (0.1-10 μM; 21 h) dose-dependently increases pre-β-HDL formation[1].
Dalcetrapib (0-30 μM; 24 h) inhibits the CETP activity of media in HepG2 in a dose-dependent manner[3].
In Vivo: Dalcetrapib (JTT-705) (30 or 100 mg/kg; p.o.; once a day for 3 days) increases plasma HDL cholesterol in rabbits[2].
Dalcetrapib (100 mg/kg; i.g.; twice daily for 7 days) significantly increases fecal elimination of neutral sterols, bile acids, and plasma HDL-cholesterol[1].
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