UKH-1114
CAS No. : 2113664-14-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $990 | In-stock |
| 10mg | $1486 | In-stock |
| 25mg | $2675 | In-stock |
| 50mg | $4280 | In-stock |
| 100mg | $6500 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117731 |
| M.Wt: | 375.43 |
| Formula: | C22H24F3NO |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
UKH-1114 is a selective TMEM97 (a sigma-2 receptor) agonist with a Ki values of 1279 and 46 nM for σ1R and σ2R/TMEM97, respectively. UKH-1114 exhibits exceptional selectivity with negligible affinity for over 50 other receptors and channels. UKH-1114 effectively relieves spared nerve injury (SNI)-induced mechanical hypersensitivity with a long-lasting duration and without motor impairment. UKH-1114 can be used for neuropathic pain research[1].
In Vivo:UKH-1114 (10 µg, i.t. once, lasting for 1-72 h) elicits pronounced and sustained antinociceptive effects, by acting as an agonist at σ2R/Tmem97 in the SNI mice model[1].
UKH-1114 (10 mg/kg, i.v., once, lasting for 0-164 h) alleviates neuropathic pain without motor impairment in the SNI mice model[1].
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