Lycoramine
CAS No. : 21133-52-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $133 | In-stock |
| 5mg | $280 | In-stock |
| 10mg | $420 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N6619A |
| M.Wt: | 289.38 |
| Formula: | C17H23NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Lycoramine is a blood-brain barrier-penetrating Acetylcholinesterase inhibitor and Galanthamine (HY-76299) derivative. Lycoramine induces Amyloid-beta plaque clearance. Lycoramine induces reversal of cognitive decline and memory improvement. Lycoramine can be used for research on Alzheimer's disease and myasthenia gravis[1][2][3].
IC50 & Target:AChE[1]
In Vitro:Lycoramine produces weaker AChE inhibition than Galanthamine (HY-76299) in the HPLC-IMER-MS bioanalytical system[1].
Lycoramine exhibits 42% higher acetylcholinesterase inhibitory activity than galantamine under in vitro conditions[3].
In Vivo:Lycoramine (4 mg/kg; i.p.; daily; 7 days) reverses cognitive decline in 12 month-old 5xFAD mice, reduces Aβ plaque load more effectively than galantamine, and induces 145 significant cortical protein alterations while being detected in all brain regions examined[3].
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