Lonaprisan
CAS No. : 211254-73-8
(Synonyms: ZK 230211; BAY86 5044)
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| Cat. No. : | HY-16290 |
| M.Wt: | 508.52 |
| Formula: | C28H29F5O3 |
| Purity: | >98 % |
| Solubility: |
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect[1]. IC50 & Target:IC50: 3.6 pM (progesterone receptor A), 2.5 pM (progesterone receptor B)
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