Ro 48-8587
CAS No. : 211120-62-6
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| Cat. No. : | HY-116244 |
| M.Wt: | 313.23 |
| Formula: | C12H7N7O4 |
| Purity: | >98 % |
| Solubility: |
Ro 48-8587 is a selective AMPA receptor antagonist with an IC50 of 8 nM. Ro 48-8587 functionally inhibits AMPA receptor activity, blocks AMPA-induced depolarization of rat cortical wedges. Ro 48-8587 can be used for the research of ischaemia and seizures[1].
In Vitro:Ro 48-8587 (1-2 h) potently inhibits [3H]AMPA, [3H]kainate and [3H]MK-801 binding to rat whole brain membranes with Ki values of 0.008, 1.3 and 8 μM[1].
Ro 48-8587 (1-10 μM) potently, competitively inhibits S-AMPA-induced depolarizations in rat brain cortical wedges with an IC50 of 0.089 μM[1].
Ro 48-8587 inhibits NMDA-induced depolarizations in rat brain cortical wedges with an IC50 of 4.4 μM[1].
Ro 48-8587 (0.5-50 nM; 1 h) binds to a single population of high-affinity sites on rat whole brain membranes with a KD of 3 ± 1 nM[1].
In Vivo:Ro 48-8587 is moderately neuroprotective in a rat focal ischaemia model, reducing cortical infarct volume by 22%[1].
Ro 48-8587 7 prevents electroshock-induced convulsions or sound-induced seizures in MORO or DBA-2 mice[1].
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