Sobetirome (GMP)

Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM^[1]. In Vivo:Sobetirome (GMP) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (GMP) (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome (GMP) reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome (GMP) increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice^[2]. Treatment with 10× Sobetirome (GMP) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GMP) induces a decrease in fat mass of 20% (1.3 g)^[3].