UMB-136
CAS No. : 2109805-83-4
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| Cat. No. : | HY-119490 |
| M.Wt: | 417.50 |
| Formula: | C24H27N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb[1].
In Vitro:UMB-136 (5 μM; 24 h) significantly induces HIV-1 reactivation[1].
UMB-136 (2.5 μM; 24 h) enhances HIV-1 transcription and viral production by releasing P-TEFb[1].
UMB-136 (2.5 or 5 μM) reverses HIV-1 latency in multiple cell models (THP89GFP, J-Lat full-length (dEnv) clones, primary CD4+ T cell) of HIV-1 latency[1].
UMB-136 (2.5 μM) synergizes with other LRAs (Prostratin HY-107421 or SAHA) to reverse HIV-1 latency in J-Lat cell lines[1].
Combined treatment with UMB-136 (2.5 μM) and PKC activators reverses HIV-1 latency in patient-derived resting CD4+ T cells[1].
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