MU380
CAS No. : 2109805-78-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $143 | In-stock |
| 5mg | $359 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-112927 |
| M.Wt: | 430.23 |
| Formula: | C15H15BrF3N7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1].
In Vitro:MU380 (100 nM, 24 h) potently inhibits CHK1 kinase and sensitizes lymphoid tumor cells to gemcitabine[1].
MU380 (400 nM, 24 h) can significantly affect the cell cycle profile and induce the death of dividing and non-dividing primary chronic lymphocytic leukemia lymphocytes[1].
In Vivo:MU380 (20 mg/kg, in 20% aqueous Kolliphor solution, every three days from day 14 to day 28) can effectively inhibit tumor growth in NOD-scid IL2Rγnull mice with tumour[1].
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