RN-9893 (hydrochloride)
CAS No. : 2109450-40-8
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| Cat. No. : | HY-110270A |
| M.Wt: | 536.95 |
| Formula: | C21H24ClF3N4O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC50 values of 0.42 and 0.66 μM, for humans and rats, respectively[1].
In Vitro:RN-9893 Hydrochloride reveals selectivity towards TRPV1 (IC50: 10 μM), TRPV3 (IC50: >30 μM) and TRPM8 (IC50: 30 μM) [1].
RN-9893 Hydrochloride inhibits rTRPV4 with an IC50 of 0.57 μM when 4α-PDD acts as an agonist. RN-9893 inhibits rTRPV4 with an IC50 of 2.1 μM when hypotonicity is used as agonist[1].
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