W-84 (dibromide)
CAS No. : 21093-51-6
(Synonyms: HDMPPA)
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $850 | In-stock |
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| Cat. No. : | HY-100979 |
| M.Wt: | 708.52 |
| Formula: | C32H44Br2N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 6.25 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 3.03 mg/mL (ultrasonic;warming;heat to 60°C) |
W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3]. IC50 & Target: muscarinic acetylcholine receptors[1] In Vitro: The stabilizing effect of W-84 (dibromide) on antagonist-receptor complexes may explain the overadditive protective action exerted by the combination of atropine and W-84 (dibromide) against organophosphate intoxication[1]. W-84 (dibromide) not only inhibits radioligand association but also strongly stabilizes antagonist-receptor complexes[2].
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