TH1834 (dihydrochloride)
CAS No. : 2108830-09-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $572 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1550 | In-stock |
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| Cat. No. : | HY-123604A |
| M.Wt: | 641.63 |
| Formula: | C33H42Cl2N6O3 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL |
TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1].
In Vitro: TH1834 dihydrochloride (0-500 μM; 1 hour; MCF7 cells) treatment significantly reduces the viability of MCF7 cells[1].
TH1834 dihydrochloride (0-500 μM; 1 hour; MCF7 cells) treatment highly significant increase in cytotoxicity[1].
TH1834 dihydrochloride (500 μM; 1 hour; MCF7 cells) treatment induces caspase 3 activation in MCF7 cells[1].
TH1834 dihydrochloride significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage in breast cancer[1].
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