Org-12962 (hydrochloride)
CAS No. : 210821-63-9
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| Cat. No. : | HY-21994 |
| M.Wt: | 302.12 |
| Formula: | C10H12Cl2F3N3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C?receptor agonist and exhibits pEC50?values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A?and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2]. In Vivo: Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].
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