CP-471474
CAS No. : 210755-45-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $74 | In-stock |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-W011085 |
| M.Wt: | 368.38 |
| Formula: | C16H17FN2O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2].
In Vivo: CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose)[2].
CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both[2].
CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months[2].
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