1,11b-Dihydro-11b-hydroxymedicarpin
CAS No. : 210537-04-5
(Synonyms: 11b-Hydroxy-11b,1-dihydromedicarpin)
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| Cat. No. : | HY-N0976 |
| M.Wt: | 288.30 |
| Formula: | C16H16O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
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