Sitaxsentan (sodium) (Standard)
CAS No. : 210421-74-2
(Synonyms: IPI 1040 (sodium) (Standard); TBC11251 (sodium) (Standard))
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| Cat. No. : | HY-11103R |
| M.Wt: | 476.89 |
| Formula: | C18H14ClN2NaO6S2 |
| Purity: | >98 % |
| Solubility: |
Sitaxsentan (sodium) (Standard) is the analytical standard of Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) (HY-11103). This product is intended for research and analytical applications. Sitaxsentan sodium is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension[1][2][3][4][5].
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- Sitaxsentan (sodium) (Standard)
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