Z-LEHD-FMK
CAS No. : 210345-04-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $250 | In-stock |
| 5mg | $750 | In-stock |
| 10mg | $1125 | In-stock |
| 25mg | $1700 | In-stock |
| 50mg | $2500 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-P1010 |
| M.Wt: | 690.72 |
| Formula: | C32H43FN6O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming) |
Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3].
IC50 & Target:caspase-9[1]
In Vitro: Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity[1].
Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis[1].
In Vivo: Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats[2].
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