Z-VDVAD-FMK
CAS No. : 210344-92-6
(Synonyms: Z-VD(OMe)VAD(OMe)-FMK)
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $300 | In-stock |
| 10mg | $495 | In-stock |
| 25mg | $895 | In-stock |
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| Cat. No. : | HY-P1008 |
| M.Wt: | 695.73 |
| Formula: | C32H46FN5O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].
In Vitro: Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death[1].
Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells[2].?
Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%[3].
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