HA-100 (dihydrochloride)
CAS No. : 210297-47-5
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| Cat. No. : | HY-12880 |
| M.Wt: | 350.26 |
| Formula: | C13H17Cl2N3O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2]. In Vitro:HA-100 dihydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].
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