Zonampanel
CAS No. : 210245-80-0
(Synonyms: YM 872)
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1750 | In-stock |
| 50mg | $2800 | In-stock |
| 100mg | $4500 | In-stock |
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| Cat. No. : | HY-15072 |
| M.Wt: | 331.24 |
| Formula: | C13H9N5O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
Zonampanel (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor. In Vitro: Zonampanel inhibits the human MRP4-mediated transport of [3H]oestradiol 17-D-glucuronide in a concentration-dependent manner. In contrast, Zonampanel (up to 1000 mM) does not inhibit the human MRP2- or BCRP-mediated transport of [3H]oestradiol 17-D-glucuronide or [3H]methotrexate[1]. Zonampanel inhibits the uptake of typical substrates by Oat1, Oat2, and Oat3 with inhibition constant (Ki) values of 7.02 to 10.4 μM. A time- and saturable concentration-dependent increase in [14C]Zonampanel uptake is observed in these cells [Km values: 13.4 to 53.6 μM][2]. In Vivo: In in vivo experiments, probenecid and cimetidine decrease intrinsic clearance for both the renal secretion and biliary excretion of Zonampanel[2].
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