AZD-0284
CAS No. : 2101291-07-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $420 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $940 | In-stock |
| 100mg | $1250 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120384 |
| M.Wt: | 524.43 |
| Formula: | C21H18F6N2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment[1].
IC50 & Target: pIC50: 7.4 (FRET RORγ)[1]
In Vitro: AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells[1].
AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17+cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R[1][2].
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