Miglustat (hydrochloride)
CAS No. : 210110-90-0
(Synonyms: N-Butyldeoxynojirimycin (hydrochloride); NB-DNJ (hydrochloride); OGT 918 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $750 | In-stock |
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| Cat. No. : | HY-17020A |
| M.Wt: | 255.74 |
| Formula: | C10H22ClNO4 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 34 mg/mL;DMSO : 65 mg/mL (ultrasonic) |
Miglustat (N-Butyldeoxynojirimycin) hydrochloride is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat hydrochloride can be used for the research of type I gaucher disease[1][2]. In Vitro:Miglustat (200 μM; 2, 4 and 24 h) hydrochloride restores F508del-CFTR (cystic fibrosis transmembrane conductance regulator) function in cystic fibrosis (CF) bronchial epithelial IB3-1 and CuFi-1 cells. Miglustat hydrochloride reduces the inflammatory response to P. aeruginosa in both CF and non-CF bronchial cells[1]. In Vivo:Miglustat (0.2 mg/kg; oral administration; once) hydrochloride is able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability[2].
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