DBCO-NHCO-PEG4-NHS ester
CAS No. : 2100306-58-7
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| Cat. No. : | HY-111456 |
| M.Wt: | 649.69 |
| Formula: | C34H39N3O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-NHCO-PEG4-NHS ester is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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- DBCO-NHCO-PEG4-NHS ester
- Cat. No.:
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