Compound E
CAS No. : 209986-17-4
(Synonyms: γ-Secretase-IN-1)
| Size | Price | Stock |
|---|---|---|
| 1mg | $160 | In-stock |
| 5mg | $520 | In-stock |
| 10mg | $830 | In-stock |
| 25mg | $1650 | In-stock |
| 50mg | $2220 | In-stock |
| 100mg | $2995 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14176 |
| M.Wt: | 490.50 |
| Formula: | C27H24F2N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. IC50 & Target:IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)[1] In Vitro:Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1].
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