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| Cat. No. : | HY-13526G |
| M.Wt: | 463.48 |
| Formula: | C26H23F2N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor[1][2].
IC50 & Target:IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM[1]
In Vitro:YO-01027 (0.25-10 μM, during 1-18 days) promotes iPSC generation from human neonatal keratinocytes[2].
YO-01027 (2 μM, 3 days) does not affect p53 activity in OCT4, SOX2-transduced human keratinocytes[2].
YO-01027 (10 μM, 3 days) promotes the proliferation of supporting cells (SCs) in cultured mouse cochleae[3].
YO-01027 (10 μM, 3 days) generates new hair cell (HCs) and increases the HCs number in neonatal mouse cochleae[3].
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