L-NMMA (citrate)
CAS No. : 209913-88-2
(Synonyms: Methylarginine (citrate); Tilarginine (citrate))
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| Cat. No. : | HY-18732B |
| M.Wt: | 380.35 |
| Formula: | C13H24N4O9 |
| Purity: | >98 % |
| Solubility: |
L-NMMA (Tilarginine) citrate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA citrate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA citrate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA citrate is applicable to research related to nociception, bone cancer pain, and myopia[1][2][3].
In Vivo:L-NMMA (50 µg; i.t.; single administration) citrate significantly alleviates bone cancer-induced mechanical allodynia and thermal hyperalgesia in mice at 2 and 12 h post-treatment[1].
L-NMMA (20 nmol; intravitreal injection; once every other day; 2 to 4 weeks) citrate alleviates choroidal fibrosis and delays myopia progression by inhibiting the NO signaling pathway in lens-induced myopic guinea pigs[2].
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