DO34 analog
CAS No. : 2098969-71-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $39 | In-stock |
| 10mg | $62 | In-stock |
| 25mg | $116 | In-stock |
| 50mg | $175 | In-stock |
| 100mg | $245 | In-stock |
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| Cat. No. : | HY-117771A |
| M.Wt: | 531.53 |
| Formula: | C26H28F3N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 105 mg/mL |
DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB1 receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation[1][2][3]. In Vitro:DO34 analog is a structural analog of DO34 (HY-117771)[1][2][3].
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