TPC-144
CAS No. : 2098621-17-9
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| Cat. No. : | HY-123577 |
| M.Wt: | 515.59 |
| Formula: | C31H31F2N3O2 |
| Purity: | >98 % |
| Solubility: |
TPC-144 is a LSD1/KDM1A inhibitor. TPC-144 inhibits LSD1, and leads to a decrease in the protein level of DNMT1, causing low methylation of the LINE-1 element. TPC-144 can also produce a synergistic effect with Decitabine (HY-A0004) (a DNMT inhibitor), jointly promoting DNA demethylation and thereby inducing differentiation and apoptosis of leukemia cells. TPC-144 has also demonstrated anti-tumor efficacy in acute myeloid leukemia (AML) models. TPC-144 can be used for the study of AML[1][2].
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