PROTAC Sirt2 Degrader-1
CAS No. : 2098487-75-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $720 | In-stock |
| 25mg | $1485 | In-stock |
| 50mg | $2380 | In-stock |
| 100mg | $3800 | In-stock |
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| Cat. No. : | HY-103636 |
| M.Wt: | 852.94 |
| Formula: | C40H40N10O8S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM)[1]. IC50 & Target:IC50: 0.25 μM (Sirt2)[1] In Vitro: PROTAC Sirt2 Degrader-1 (Compound 12; 10 μM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].
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