R-10015
CAS No. : 2097938-51-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $720 | In-stock |
| 50mg | $1150 | In-stock |
| 100mg | $1750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120097 |
| M.Wt: | 410.86 |
| Formula: | C20H19ClN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1[1].
IC50 & Target: IC50: 38 nM (human LIMK1)[1]
In Vitro: R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells[1].
R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release[1].
R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) [1].
In Vivo: R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections[1].
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