JAK-IN-5
CAS No. : 2096999-92-5
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| Cat. No. : | HY-111471 |
| M.Wt: | 474.57 |
| Formula: | C27H31FN6O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
JAK-IN-5 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.
IC50 & Target: JAK[1]
In Vivo: JAK-IN-5 (compound 1) (oral aspirate, 0.5 mg/mL, 50 μL ) inhibits STAT6 phosphorylation by 60% in IL-13-induced in lung tissue in a mouse model of pSTAT6 induction[2].
JAK-IN-5 (compound 1) (oral aspirate, 0.1-1.0 mg/mL, 50 μL) inhibits 88% of BALF eosinophils in male C57 mice model of Alternaria alternata-induced eosinophilic inflammation of the lung[2].
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