Mefluleucine
CAS No. : 2095886-80-7
(Synonyms: NV-5138)
| Size | Price | Stock |
|---|---|---|
| 5mg | $275 | In-stock |
| 10mg | $440 | In-stock |
| 25mg | $935 | In-stock |
| 50mg | $1485 | In-stock |
| 100mg | $2145 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114384 |
| M.Wt: | 181.18 |
| Formula: | C7H13F2NO2 |
| Purity: | >98 % |
| Solubility: |
Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies[1][2].
IC50 & Target:mTORC1[1].
In Vivo:Mefluleucine (NV-5138) is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~3 h determined following intravenous and oral dosing in rats[1].
Mefluleucine (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC[2].
Mefluleucine (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects[2].
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