CSF1R-IN-1
CAS No. : 2095849-04-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $270 | In-stock |
| 10mg | $420 | In-stock |
| 25mg | $840 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101774 |
| M.Wt: | 479.45 |
| Formula: | C25H20F3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM. IC50 & Target: IC50: 0.5 nM (CSF1R)[1] In Vitro: CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay[1]. In Vivo: CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1].
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