RIP1 kinase inhibitor 1
CAS No. : 2095515-38-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 50mg | $1900 | In-stock |
| 100mg | $2900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111409 |
| M.Wt: | 461.90 |
| Formula: | C24H20ClN5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. IC50 & Target: pKi: 9.04 (RIP1 kinase)[1] In Vitro: RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC50=15 nM; pMLKL, IC50=2.7 nM)[1].
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