MA-0204

Cat. No. :	HY-114739
M.Wt:	476.49
Formula:	C25H27F3N2O4
Purity:	>98 %
Solubility:	DMSO : 43.33 mg/mL (ultrasonic)

Introduction of 2095128-17-7 :

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC₅₀s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)^[1]. IC50 & Target: EC50: 0.4 nM (human PPARδ), 7.9 nM (mouse PPARδ) and 10 nM (rat PPARδ)^[1] In Vitro: MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C^[1].

MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice^[1].

MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts^[1].

In Vivo: PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle^[1].