AFM-30a
CAS No. : 2095107-57-4
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| Cat. No. : | HY-125099 |
| M.Wt: | 466.51 |
| Formula: | C24H27FN6O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].
IC50 & Target:EC50: 9.5 μM (PAD2); 0.4 μM (H3 citrullination)[1]
In Vitro: AFM-30a (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM[1].
AFM-30a shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM[1].
In Vivo: AFM-30a suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2].
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