OTS186935
CAS No. : 2093400-18-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $500 | In-stock |
| 25mg | $1000 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $1950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122181 |
| M.Wt: | 463.96 |
| Formula: | C25H26ClN5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1]. IC50 & Target: IC50: 6.49 nM (SUV39H2)[1] In Vitro: OTS186935 inhibits A549 cell growth with an IC50 of 0.67 μM[1]. In Vivo: OTS186935 (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1].
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