Lenalidomide-C4-NH2
CAS No. : 2093388-69-1
(Synonyms: Cereblon ligand 1; Lenalidomide Butanamine)
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| Cat. No. : | HY-115446 |
| M.Wt: | 315.37 |
| Formula: | C17H21N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lenalidomide-C4-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1]. IC50 & Target:E3 ligase[1].
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