PROTAC BET degrader-2
CAS No. : 2093388-33-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $480 | In-stock |
| 10mg | $760 | In-stock |
| 50mg | $2300 | In-stock |
| 100mg | $3680 | In-stock |
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| Cat. No. : | HY-114228 |
| M.Wt: | 770.84 |
| Formula: | C41H42N10O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
PROTAC BET degrader-2 is a BET PROTAC degrader. PROTAC BET degrader-2 induces dose-dependent degradation of BRD2, BRD3 and BRD4 proteins in leukemia cells. PROTAC BET degrader-2 inhibits the growth of acute leukemia cells. PROTAC BET degrader-2 can be used for the research of acute leukemia[1].
IC50 & Target:IC50: 9.6 nM (BET in the RS4;11 leukemia cell line)[1].
In Vitro:PROTAC BET degrader-2 (Compound 25) (4 days) inhibits the proliferation of human acute leukemia cells RS4;11 and MOLM-13, with IC50 values of 9.6 and 72.3 nM[1].
PROTAC BET degrader-2 (10-100 nM; 3 h) induces dose-dependent degradation of BRD2, BRD3 and BRD4 proteins in human acute leukemia cell line RS4;11, and effectively reduces the expression of BRD3 and BRD4 at a concentration of 10 nM after 3 h of incubation[1].
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- HY-114228
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