PROTAC BET Degrader-1


CAS No. : 2093386-22-0

2093386-22-0
Price and Availability of CAS No. : 2093386-22-0
Size Price Stock
5mg $550 In-stock
10mg $850 In-stock
25mg $1850 In-stock
50mg $2775 In-stock
100mg $4000 In-stock
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Cat. No. : HY-103633
M.Wt: 871.90
Formula: C44H45N11O9
Purity: >98 %
Solubility: DMSO : ≥ 50 mg/mL
Introduction of 2093386-22-0 :

PROTAC BET Degrader-1 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration. IC50 & Target:BET[1] In Vitro: PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells[1].

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