PROTAC BET Degrader-1
CAS No. : 2093386-22-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $550 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1850 | In-stock |
| 50mg | $2775 | In-stock |
| 100mg | $4000 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103633 |
| M.Wt: | 871.90 |
| Formula: | C44H45N11O9 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
PROTAC BET Degrader-1 is a BRD2/BRD3/BRD4 PROTAC degrader. PROTAC BET Degrader-1 inhibits the growth of acute leukemia cells. PROTAC BET Degrader-1 is applicable to the research of acute leukemia[1].
IC50 & Target:BET[1]
In Vitro:PROTAC BET Degrader-1 (Compound 9) (4 days) potently inhibits the proliferation of RS4;11 and MOLM-13 acute leukemia cells, with IC50 values of 4.3 and 45.5 nM[1].
PROTAC BET Degrader-1 (3-30 nM; 3 hours) effectively degrades BRD2, BRD3 and BRD4 proteins in RS4;11 acute leukemia cells[1].
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