Fosmanogepix
CAS No. : 2091769-17-2
(Synonyms: APX001; E1211)
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|---|---|---|
| 1mg | $290 | In-stock |
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| Cat. No. : | HY-119726 |
| M.Wt: | 468.40 |
| Formula: | C22H21N4O6P |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;adjust pH to 4 with HCl) |
Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research[1].
IC50 & Target:Gwt1[1]
In Vitro: Fosmanogepix (APX001) (2-0.002 μg/ml, 40-72 h) inhibited the growth of C. neoformans, C. gattii, Candida albicans, and Aspergillus fumigatus with MIC or minimum effective concentration (MEC) values ranging from 0.008-0.25 μg/ml[1].
In Vivo: Fosmanogepix (APX001) (390 mg/kg for Oral gavage, thrice daily) reduced the fungal burden in mouse cryptococcal meningitis (CM) model[1].
Fosmanogepix (APX001) (100 mg/kg for Oral gavage) is the driver of efficacy in CD-1 mice[1].
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