Golidocitinib
CAS No. : 2091134-68-6
(Synonyms: AZD4205)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $490 | In-stock |
| 100mg | $780 | In-stock |
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| Cat. No. : | HY-107361 |
| M.Wt: | 489.57 |
| Formula: | C25H31N9O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM)[1]. IC50 & Target: IC50: 73 nM (JAK1), >14.7 μM (JAK2), >30 μM (JAK3)[1] In Vitro: Golidocitinib (Example 32) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2, and shows little inhibition on JAK3 (IC50, >14.7, >30 μM, respectively). Golidocitinib significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells with an IC50 of 161 nM[1]. In Vivo: Golidocitinib (12.5 mg/kg BID (twice daily), 25 m/kg BID or 50 mg/kg BID, p.o.) alone has increasing antitumor effects, and ehances the antitumor activity of osimertinib, compared to treatment with osimertinib alone in mice bearing NCI-H1975 cells[1].
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