SGN-2FF
CAS No. : 2089647-47-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $680 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107366 |
| M.Wt: | 166.15 |
| Formula: | C6H11FO4 |
| Purity: | >98 % |
| Solubility: | H2O : 36.67 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1]. IC50 & Target: Fucosyltransferase[1] In Vitro: SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner[1]. In Vivo: SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model[1].
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