MZH29
CAS No. : 2089590-80-5
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| Cat. No. : | HY-115443 |
| M.Wt: | 560.62 |
| Formula: | C31H33FN4O5 |
| Purity: | >98 % |
| Solubility: |
MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML)[1].
In Vivo:MZH29 (1 mg/kg, p.o.) causes complete tumor regression and extends survival in a mouse model of AML with less toxicity[1].
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