VT-1598
CAS No. : 2089320-99-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $380 | In-stock |
| 10mg | $620 | In-stock |
| 25mg | $1250 | In-stock |
| 50mg | $2000 | In-stock |
| 100mg | $3200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123777 |
| M.Wt: | 584.52 |
| Formula: | C31H20F4N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris[1][2]. VT-1598 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro:VT-1598 (0.015-8 μg/mL; 24 h) demonstrates in vitro activity against C. auris[1].
VT-1598 (0.03125-0.125 μg/mL; 24 h) shows highly effects in inhibiting the in vitro growth of clinical Candida isolates[2]. In Vivo:VT-1598 (oral gavage; 5, 15, and 50 mg/kg; once daily; 7 d) treatment shows a significant and dose-dependent survival advantage, and dose-dependent reductions in fungal burden[1].
VT-1598 (oral gavage; 3.2, 8, and 20 mg/kg; once daily; 4 d) is present to a great extent in the plasma and tongue after oral administration in Act1-deficient mice infected with C. albicans[2].
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