Elrelesertib (Standard)
CAS No. : 2089288-03-7
(Synonyms: AZD1390 (Standard))
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| Cat. No. : | HY-109566R |
| M.Wt: | 477.57 |
| Formula: | C27H32FN5O2 |
| Purity: | >98 % |
| Solubility: |
Elrelesertib (Standard) (AZD1390 (Standard)) is the analytical standard of Elrelesertib (AZD1390) (HY-109566). This product is intended for research and analytical applications. Elrelesertib (AZD1390) is an orally active, brain-penetrant ATM kinase inhibitor with IC50 values of 0.78 nM. Elrelesertib blocks ATM-dependent DNA damage response, inhibits ATM autophosphorylation and downstream Chk2, Rad50 phosphorylation, and accumulates at DNA breaks. Elrelesertib acts as a radiosensitizer, induces apoptosis, genomic instability, G2-M cell cycle arrest, ROS elevation, and mitochondrial membrane potential alteration. Elrelesertib has low efflux liability against P-gp and BCRP. Elrelesertib can be used for the research of central nervous system malignancies, glioblastoma multiforme, glioma, lung cancer brain metastases, and breast cancer[1][2][3]. IC50 & Target:ATM[1]
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- Elrelesertib (Standard)
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