AZD1390
CAS No. : 2089288-03-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $590 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $960 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-109566 |
| M.Wt: | 477.57 |
| Formula: | C27H32FN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell[1]. IC50 & Target: ATM[1] In Vivo: Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390[2].
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