SRPKIN-1
CAS No. : 2089226-94-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 50mg | $1650 | In-stock |
| 100mg | $2250 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116856 |
| M.Wt: | 472.53 |
| Formula: | C27H21FN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 110 mg/mL |
SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. IC50 & Target: IC50: 35.6 nM (SRPK1), 98 nM (SRPK2)[1] In Vitro: SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) significantly reduces SR protein phosphorylation at the steady state with or without washout[1].
SRPK-IN-1 potently converts VEGF from pro-angiogenic to anti-angiogenic isoform[1].
In Vivo: SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis in a CNV mouse model through VEGF alternative splicing[1].Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
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