JVW-1009
CAS No. : 2089059-30-1
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| Cat. No. : | HY-116968 |
| M.Wt: | 340.47 |
| Formula: | C24H24N2 |
| Purity: | >98 % |
| Solubility: |
JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R Ki = 96 nM; Sig2R Ki = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease[1].
In Vitro:JVW-1009 binds to purified Sig1R (Ki = 96 nM) and Sig2R (Ki = 70 nM) with approximately equivalent affinity[1].
JVW-1009 (200 μM; 5-day) significantly reduces age-dependent neurodegeneration of VC4 and VC5 cholinergic neurons in SC_APP *Caenorhabditis elegans* via a PGRMC1-mediated pathway[1].
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