Dot1L-IN-1
CAS No. : 2088518-50-5
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| Cat. No. : | HY-101520 |
| M.Wt: | 646.21 |
| Formula: | C32H36ClN9O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dot1L-IN-1 is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of <0.1 nM. Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively[1].
IC50 & Target:Ki: 2 pM (Dot1L)[1]
IC50: <0.1 nM (Dot1L)[1]
In Vitro:Dot1L-IN-1 (analogue 7) effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50=5 nM)[1].
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