AZ31
CAS No. : 2088113-98-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-112198 |
| M.Wt: | 420.50 |
| Formula: | C24H28N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of <1.2 nM for ATM enzyme, and an IC50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer[1]. IC50 & Target:IC50: <1.2 nM (ATM enzyme), 46 nM (ATM, in cell)[1] In Vitro:AZ31 (0.3-3 μM; 1 h) affects phosphorylation of a panel of ATM targets[1]. AZ31 (10 μM; 1 h) affects stabilization of p53 in H2228 lung cancer cells after radiation[1]. In Vivo:AZ31 (50-100 mg/kg; p.o. twice a day) shows low brain coverage[1].
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